Endocrine Abstracts

Introduction: Diabetes mellitus (DM) is a metabolic illness caused by insulin resistance or lack of it. Hypertension (HT) has been seen frequently in diabetic patients, and causes morbidity and mortality with its complications. Salusins are vasodilator and hypotensive peptids which function most in cardiovascular system. Apelin is an insulin-sensitive, vasoconstructive, positive inotropic-effective peptide. In this study, determining the levels of serum salusin-α, salusin...

Purpose: The purpose of this study was to analyse ghrelin concentrations in the umbilical cord of pregnant women with a diagnosis of gestational diabetes mellitus. The relationship between ghrelin concentrations and birth weights was investigated.Materials and methods: Sixty pregnant women with gestational diabetes mellitus and 64 healthy pregnant women with three oral glucose tolerance test results within normal limits were included in the study. Follow...

Introduction: Diabetes mellitus is an important public health problem due to defects of the effect of the insulin or insulin deficiency, accompanied by chronic microvascular complications with diabetic nephropathy is characterised by proteinuria that the increasing number of patients progress to end stage renal disease. Many peptide hormone made in etiopathogenesis is situated, although adropin which discovered in recent years involves in glucose homeostasis, its relation to d...

Background: Fahr’s disease is a rare degenerative disorder characterized by symmetrical and bilateral intracranial calcification. Movement disorders are the most common symptoms of Fahr’s disease and dystonia is an uncommon presentation which accounts for only 8% of symptomatic patients.Case report: A 47 years old female admitted to emergency department with involuntary movements of extremities and anxiety. Neurological examination was normal e...

Introduction: Chemerin is a novel adipokine that is correlated with adipocyte differentiation, glucose metabolism and inflammation, but its role remains to be elucidated in atherosclerosis particularly in diabetes and prediabetes. We aimed to investigate the relation of serum chemerin levels with markers of atherosclerosis as exemplified by pulse wave velocity (PWV), carotid intima media thickness (CIMT), and carotid plaque presence in these groups.Metho...

Angiosarcoma of the thyroid is a rare and aggressive primary malignant tumor of the thyroid: it rarely occurs in that organ and most of these occur mainly in patients from the mountainous Alpine regions. We report a case of 68-year-old female who presented at our hospital with a rapidly enlarging neck mass associated with compressive symptoms. On clinical examination, the thyroid gland appeared firm during the acts of deglutition. The results of thyroid function tests were for...

Aim: Diabetic foot is a devastating complication of diabetes mellitus. Many factors such as neuropathy, vascular injury and infection contribute in the development of diabetic foot. Programmed cell death is a pathway that causes a tendency for the development of atherosclerosis. Whereas Fas/Fas ligand pathway induces apoptosis, osteoprotegerin (OPG) causes calcification in vascular area and also effects apoptotic pathway. In the present study, we aimed to investigate the role ...

Background/purpose: The combination of DM and HT accelerates vascular complications and increases the risk of mortality and morbidity. Hypertension is seen in half of diabetic patients. HT can be detected in approximately 40% of newly diagnosed diabetic patients. DM frequency increased 2.5 times in hypertensive patients. The association of HT and DM is due to the common mechanism responsible for the pathogenesis of both diseases. There is a limited number of studies investigat...

IntroductionParaneoplastic hypercalcemia is extremely rare in the pediatric population, requiring urgent treatment. Pediatric malignancy-related hypercalcemia (PMRH) has been associated with rhabdomyosarcoma (RMS). Hypercalcemia with elevated parathyroid hormone (PTH), ectopic PTH secretion, is rarer (< 1% of cases). Reports of the use of Zoledronic Acid (ZA) as a second line bisphosphonate are limited. The monoclonal antibody, Denosumab, which inhib...

Introduction: Hypopituitarism is a clinical syndrome that develops as a result of inadequate production and release of one or more pituitary hormones. The prevalence is 45/100,000 and the incidence is 4/100,000 cases/year. Here, we aimed to present a patient with complete pituitary hormone deficiency.Case: A 75-year-old woman had been followed up with hypertension for 20 years and osteoporosis for 16 years. She underwent surgery 7 years ago for a femur f...